Like other members of the Euphorbia genus, euphorbia jolkinii produces a milky sap, called latex, that is moderately toxic when in direct contact with the skin. Getting this sap on your skin can cause serious discomfort as it's an irritant, even causing blisters in some individuals. The repercussions are even more damaging if you get the sap in your eye, as it can result in conjunctivitis, characterised by bloodshot eyes, itching, a burning sensation, and pus. It can also potentially lead to blindness. It's likely to cause swelling of the lips, tongue, and throat if ingested.