Trichosanthes requires considerable care to thrive, benefiting from bright, indirect sunlight, consistent moisture, and warm temperatures. They prefer a well-draining, fertile soil mixture. Common challenges may include pests such as aphids and spider mites, as well as root rot from overwatering. Seasonally, trichosanthes needs protection from extreme temperatures, with reduced watering in winter and vigilance for proper ventilation and humidity in the hot summer months.