Originating from regions with variable moisture, aextoxicon has adapted to withstand periods of low water availability, exhibiting a moderate drought tolerance. Its native habitat's fluctuating water conditions have informed its watering needs; hence, it thrives best when watered once every 2-3 weeks. Cultivation should mimic this pattern to maintain the plant's health and vigor. Typically grown outdoors due to its resilience, aextoxicon often enters a state of dormancy during which its water requirements further diminish – an adaptation crucial for surviving in climates where water is not always plentiful.