Primary propagation methods for curio are through stem cuttings and seeds. Key factors for success include ensuring high humidity, warm temperatures, and using a well-draining soil mix. Cuttings require careful handling to avoid sap exposure, which can be an irritant. Propagation by cuttings is generally easy, although seeds might present a moderate challenge. To propagate, take a stem cutting, let it callous over a few days, plant in soil, and maintain consistent moisture without overwatering. Overall, with the right conditions and care, gardeners can successfully propagate curio.