Cowbane thrives in environments that mimic its native wetland habitat, requiring consistent moisture to maintain its health. This species is adapted to regular hydration and does not tolerate drought well. It prefers a balance of water retention and drainage, indicative of its natural setting. For optimal growth, cowbane should be watered every week. As an aquatic perennial commonly grown outdoors, cowbane's ability to thrive is greatly influenced by the surrounding water quality and soil saturation levels.