Apodolirion thrive in environments that mimic their natural habitat, requiring well-drained soil and exposure to bright but indirect light. Watering should be moderate, allowing the soil to dry out slightly between sessions, with care taken not to overwater. They prefer consistent, mild temperatures and can be sensitive to extreme cold. Common challenges include susceptibility to bulb rot and attacks by pests such as aphids. Seasonally, apodolirion might enter a dormant period, reducing the need for watering and fertilization, and they may require protection or relocation during harsh winters.