Jepsonia is a moderately finicky plant genus, requiring careful management of environmental conditions. Basic care needs include partial shade to full sun, moderately moist, well-drained soils, and mildly cool temperatures, with higher humidity levels facilitating growth. Challenges may encompass pests such as snails, slugs, and root rot disease if overwatered or in poorly drained soil. For seasonal considerations, jepsonia does not tolerate frost well and needs extra warmth and humidity during winters. It tends to enter dormancy during summer, reducing its need for watering.