Cow itch tree thrive in environments that replicate their native coastal habitats, favoring full sun exposure, moderate watering, and well-draining soil with a preference for sandy substrates that offer good aeration. Gardeners should be vigilant for challenges such as susceptibility to wind stress, and potential issues with pests like scales and mealybugs. During colder seasons, cow itch tree requires protection from frost, while in the growing months of spring and summer, consistent moisture and light pruning to shape the canopy are beneficial. Autumn care entails reducing water as the plant enters dormancy.