Lophophora requires bright, indirect light and well-draining soil with good airflow to thrive. Watering should be infrequent, allowing the soil to dry between waterings. They prefer consistent temperatures, avoiding frost. Common challenges include root rot from overwatering and pest infestations such as scale insects. Seasonally, lophophora enters dormancy in winter, reducing the need for water, while in growing seasons (spring and summer), more vigilant care is required.