Melicytus is known for its adaptability in various environments, but it thrives best in conditions that mimic its native habitat. It requires a balance of sunlight and shade, preferring bright, indirect light. Soil should be well-draining and fertile, with a moderate water regimen, allowing the soil to dry slightly between waterings. Melicytus is generally resilient but can face challenges from pests such as scale insects and aphids, and it's susceptible to root rot if overwatered. Seasonally, melicytus may need protection from extreme temperatures and adjustments in watering frequency.