Mukdenia require partial shade to full shade settings, thriving in consistently moist, well-draining soil with a preference for a cooler climate. They struggle in hot, dry conditions. The genus is particularly vulnerable to slug and snail damage. During spring, mukdenia benefit from protection against late frosts and require increased hydration as they grow. In summer, mukdenia should be shielded from intense heat, while autumn is a time for maintaining moisture levels without overwatering. In winter, mukdenia's soil should not be allowed to completely dry out, despite their dormant state.