The cowbane genus requires moderate light and well-drained, moist soil. It thrives in slightly warm to mildly cool temperatures. Pests, particularly aphids and whiteflies, and plant diseases, like leaf spot and powdery mildew, are common challenges. Seasonally, these perennials require more water in summer and less in winter. Lower sunlight exposure during autumn and winter may necessitate lighting adjustments. Regular inspection for pests, especially in spring and summer, and seasonal adjustments in watering and light are recommended.